Senior Principal, Statistical Programmer

Role summary

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The Senior Principal, Statistical Programmer leads the design, development, validation and delivery of statistical programming outputs for clinical studies and regulatory submissions. Requirements typically include a degree in statistics, mathematics, computer science or a related discipline, substantial pharmaceutical or clinical-trial programming experience, and strong SAS expertise; knowledge of CDISC standards, SDTM, ADaM, TLF production and submission documentation is highly valued. The successful candidate is expected to provide technical leadership, oversee complex programming activities, ensure data quality and compliance with SOPs and regulations, and collaborate effectively with statisticians, data managers, clinical teams and regulatory colleagues. Strong communication, problem-solving, mentoring and project-management skills are essential.

About the employer

Novartis is a global medicines company headquartered in Basel, Switzerland, focused on discovering and developing innovative treatments for major diseases. Its work spans areas such as cardiovascular, renal and metabolic diseases, immunology, neuroscience, oncology and rare diseases. The company combines scientific research, clinical development, advanced data capabilities and commercial expertise to bring medicines to patients worldwide. Novartis operates internationally and employs professionals across research, clinical operations, manufacturing, technology, regulatory affairs and corporate functions. In the United Kingdom, it supports clinical development, medical affairs, market access and commercial activities, working with healthcare professionals, researchers and public health organisations. The company promotes an inclusive, international working environment and places emphasis on patient impact, scientific innovation, ethical conduct, collaboration and continuous learning.

Working in United Kingdom

The United Kingdom offers strong opportunities in pharmaceuticals, biotechnology, healthcare, technology, finance and professional services, with major employment centres in London, Cambridge, Oxford, Stevenage, Manchester and Edinburgh. Its culture is generally diverse and professional, with an emphasis on personal independence, punctuality and work-life balance. Lifestyle options range from busy city living to quieter coastal and rural communities; public transport is widely available, though housing costs vary significantly. International applicants normally need permission to work, commonly through a Skilled Worker visa. Eligibility depends on an approved employer, an eligible occupation and meeting the applicable salary and English-language requirements. Employers such as Novartis may be licensed sponsors, but sponsorship should be confirmed for the specific vacancy. Relocating workers should budget for rent, deposits, transportation, healthcare-related immigration charges and settling-in costs.