CMC Lead, Lifecycle Management, Small Molecules

Role summary

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Takeda is seeking a CMC Lead to manage lifecycle activities for small-molecule medicines in Japan. The role typically requires a degree in pharmaceutical sciences, chemistry, chemical engineering, or a related discipline, together with substantial experience in CMC development, manufacturing, technical transfer, process validation, regulatory submissions, and post-approval changes. Experience working with global cross-functional teams, contract manufacturers, and health authorities is highly desirable. Candidates should understand ICH guidelines, pharmaceutical quality systems, risk management, and the commercial lifecycle of products. Strong project leadership, communication, problem-solving, and English-language skills are expected. The successful candidate will coordinate technical strategy, ensure product supply and compliance, and lead improvements throughout the product lifecycle.

About the employer

Takeda Pharmaceutical Company is a global, research-driven biopharmaceutical company headquartered in Japan. Founded in 1781, it has developed into one of the country's largest pharmaceutical businesses, with operations and employees across many countries. Takeda focuses on therapies in areas including gastroenterology, rare diseases, neuroscience, oncology, and vaccines. Its work covers discovery, clinical development, manufacturing, regulatory affairs, and commercial operations. The company emphasizes patient-focused innovation, scientific collaboration, ethical conduct, and a diverse international workforce. Takeda's Japanese organization supports global product development and supply, making roles in CMC, manufacturing science, quality, and regulatory strategy particularly important. Employees may work with international teams, external manufacturing partners, and Japanese and overseas health authorities. Benefits and working arrangements vary by position, location, and employment grade.

Working in Japan

Japan offers strong opportunities in pharmaceuticals, biotechnology, advanced manufacturing, engineering, technology, healthcare, and research, especially around Tokyo, Osaka, and major industrial hubs. Workplace culture values preparation, reliability, teamwork, respect, and attention to detail, although international companies often use more flexible and English-friendly practices. Life includes excellent public transport, high-quality healthcare, safe cities, rich food traditions, and easy access to mountains, beaches, and historic areas. Housing and commuting costs are highest in Tokyo; Osaka and regional cities can be more affordable. Foreign professionals generally need an appropriate work visa, commonly an Engineer/Specialist in Humanities/International Services or a highly skilled professional status, with employer sponsorship. Relocation usually involves residence registration, health insurance, a bank account, and tax procedures. Learning basic Japanese is highly beneficial for daily life and workplace integration.