Drug Substance Lead, Downstream Bioprocess Science, Chemical & Biological Technology Labs, PR&D

Role summary

Written by MyIslandJob from the job title and employer. See the employer's page for the full description.

Astellas is seeking a senior scientist or technical lead to direct downstream bioprocess development for drug substances within its Chemical and Biological Technology Labs in Pharmaceutical Research and Development. The role is expected to design and optimize purification processes, lead laboratory studies, interpret analytical and process data, and support technology transfer and development programs. Candidates should have strong experience in downstream bioprocessing, protein or biologics purification, chromatography, filtration, process characterization, and scale-up. A relevant degree in biochemical engineering, biotechnology, pharmaceutical sciences, chemistry, or a related field is typically required, along with project leadership, scientific communication, documentation, and collaboration skills. Experience working in regulated pharmaceutical environments and with cross-functional or international teams would be advantageous.

About the employer

Astellas Pharma Inc. is a Japan-based global pharmaceutical company headquartered in Tokyo. It focuses on discovering, developing, manufacturing, and commercializing innovative medicines for patients with significant unmet medical needs. Its research and development activities span areas including oncology, immunology, neuroscience, urology, and specialized biologic and small-molecule therapies. Astellas operates research, manufacturing, and commercial organizations across Japan, North America, Europe, and other international markets. The company emphasizes scientific innovation, patient-focused development, responsible business conduct, and collaboration with academic, biotechnology, and healthcare partners. The PR&D organization supports the transition of promising scientific discoveries into robust, scalable, and manufacturable drug products. This position sits within an advanced technology environment where bioprocess science, process development, analytical understanding, and cross-functional teamwork contribute to future medicines.