Astellas is seeking a senior scientist or technical lead to direct downstream bioprocess development for drug substances within its Chemical and Biological Technology Labs in Pharmaceutical Research and Development. The role is expected to design and optimize purification processes, lead laboratory studies, interpret analytical and process data, and support technology transfer and development programs. Candidates should have strong experience in downstream bioprocessing, protein or biologics purification, chromatography, filtration, process characterization, and scale-up. A relevant degree in biochemical engineering, biotechnology, pharmaceutical sciences, chemistry, or a related field is typically required, along with project leadership, scientific communication, documentation, and collaboration skills. Experience working in regulated pharmaceutical environments and with cross-functional or international teams would be advantageous.
Astellas Pharma Inc. is a Japan-based global pharmaceutical company headquartered in Tokyo. It focuses on discovering, developing, manufacturing, and commercializing innovative medicines for patients with significant unmet medical needs. Its research and development activities span areas including oncology, immunology, neuroscience, urology, and specialized biologic and small-molecule therapies. Astellas operates research, manufacturing, and commercial organizations across Japan, North America, Europe, and other international markets. The company emphasizes scientific innovation, patient-focused development, responsible business conduct, and collaboration with academic, biotechnology, and healthcare partners. The PR&D organization supports the transition of promising scientific discoveries into robust, scalable, and manufacturable drug products. This position sits within an advanced technology environment where bioprocess science, process development, analytical understanding, and cross-functional teamwork contribute to future medicines.
Japan offers opportunities in pharmaceuticals, biotechnology, engineering, technology, healthcare, manufacturing, finance, and education, especially around Tokyo, Osaka, Yokohama, Kobe, and regional research clusters. Workplace culture generally values punctuality, preparation, teamwork, respect for hierarchy, and careful attention to quality. International companies are increasingly using English, although Japanese ability can significantly improve daily life and career prospects. Japan provides excellent public transport, healthcare, safety, food, and cultural experiences, but housing and living costs are high in major cities. Foreign professionals normally need an employer-sponsored work visa, commonly under an Engineer, Specialist in Humanities, International Services, or highly skilled professional category. Employers usually support visa paperwork, but applicants must provide qualifications and employment documents. Relocation planning should cover housing guarantees, residence registration, health insurance, taxes, banking, and language support. Japan has four distinct seasons and varied geography, from Hokkaido in the north to Okinawa in the south.
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