Drug Substance Lead, Upstream Bioprocess Science, CBTL, Product Research & Development

Role summary

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This role leads upstream bioprocess science for drug-substance development within Astellas’s Product Research & Development organization. Candidates are typically expected to hold an advanced degree in biotechnology, biochemistry, chemical engineering, pharmaceutical sciences, or a related discipline, with substantial experience in mammalian or microbial cell culture, bioreactor development, process characterization, and scale-up. The position requires strong knowledge of development principles, data analysis, technical documentation, and collaboration with analytical, formulation, manufacturing, and regulatory teams. A successful candidate will provide scientific leadership, solve complex process challenges, communicate clearly with internal and external partners, and help deliver robust, scalable processes supporting clinical and commercial programs.

About the employer

Astellas Pharma Inc. is a Japan-based global pharmaceutical company headquartered in Tokyo, with research, development, manufacturing, and commercial operations across multiple regions. The company focuses on innovative medicines in areas such as oncology, immunology, neuroscience, ophthalmology, and urology. Astellas invests substantially in research and development, including biologics, advanced modalities, regenerative medicine, and other emerging technologies. Its Product Research & Development organization works to translate scientific discoveries into medicines for patients with significant unmet medical needs. The company employs international, multidisciplinary teams and collaborates with academic institutions, biotechnology companies, healthcare professionals, and other industry partners. In Japan, Astellas offers opportunities in laboratory science, bioprocessing, clinical development, manufacturing, regulatory affairs, corporate functions, and commercial operations. Benefits and working arrangements vary by position and employment contract.